The IDB, together with Wayra and the World Tourism Organization, launched a "Smart Challenge" in 2021 to accelerate tourism in the Jesuit Route.

Applicant startups could be from any sector, in a growth phase, legally constituted in at least one of the five member countries (Argentina, Bolivia, Brazil, Paraguay and Uruguay) and with an innovative proposal. The winners of the call participated in an acceleration programme managed by Wayra through which, for 12 weeks, they received specialised technical support to strengthen the performance of their projects, including commercial acceleration, validation of feasibility plans, strengthening and coaching activities, identification of scalability opportunities, and networking with corporates and investors, among other areas of support.